故事聚焦奉命奔赴浣熊市的医疗速递员布莱恩（奥斯汀·艾布拉姆斯 饰），意外深陷全城失控的病毒浩劫。浣熊市彻底沦陷，异变怪物横行肆虐、嗜血猎捕，身陷末日绝境的他，能否在这场惊魂噩梦中突围求生，搏出一线生机？
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